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عمومی::
کلسیم فولینات
Combination therapy with calcium folinate
Fluorouracil/calcium folinate:
Calcium folinate can increase the risk of toxicity from Fluorouracil, especially in elderly or debilitated patients.
If calcium folinate and Fluorouracil are combined, the dose of Fluorouracil must be reduced to a greater degree in the event of toxicity than when Fluorouracil is administered alone.
Treatment with a combination of Fluorouracil and calcium folinate should not be initiated or continued in patients with gastrointestinal side effects (gastrointestinal toxicity), regardless of the severity, until the patient exhibits no further symptoms.
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